A trek through the probable universe

The Most Probable Size of the Universe

It has recently been suggested, by Firouzjahi, Sarangi, and Tye, that string-motivated modifications of the Hartle-Hawking wave function predict that our Universe came into existence from “nothing” with a de Sitter-like spacetime geometry and a spacetime curvature similar to that of “low-scale” models of Inflation. This means, however, that the Universe was quite large at birth. It would be pre...

Medical ethics through the Star Trek lens.

The Atacama Desert Trek: Outcomes

In June and July 1997, Nomad, a planetary-relevant mobile robot, traversed more than 220 kilometers across the barren Atacama Desert in Chile, exploring a landscape analogous to the surfaces of the Moon and Mars. In this unprecedented demonstration, Nomad operated both autonomously and under the control of operators thousands of kilometers away, addressing issues of robot configuration, communi...

A synaptic trek to autism.

Autism spectrum disorders (ASD) are diagnosed on the basis of three behavioral features namely deficits in social communication, absence or delay in language, and stereotypy. The susceptibility genes to ASD remain largely unknown, but two major pathways are emerging. Mutations in TSC1/TSC2, NF1, or PTEN activate the mTOR/PI3K pathway and lead to syndromic ASD with tuberous sclerosis, neurofibro...

Brainstorming through the Sequence Universe: Theories on the Protein Problem

Just as physicists strive to develop a TOE (theory of everything), which explains and unifies the physical laws of the universe, the life-scientist wishes to uncover the TOE as it relates to cellular systems. This can only be achieved with a quantitative platform that can comprehensively deduce and relate protein structure, functional, and evolution of genomes and proteomes in a comparative fas...